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Creatine kinase B is necessary to limit myoblast fusion during myogenesis PDF available through Get Fulltext Research

Adriana Simionescu-Bankston Christophe Pichavant James P. Canner Luciano H. Apponi Yanru Wang Craig Steeds John T. Olthoff Joseph J. Belanto James M. Ervasti Grace K. Pavlath ...

Published in AJP Cell Physiology

Myoblast fusion is critical for proper muscle growth and regeneration. During myoblast fusion, the localization of some molecules is spatially restricted; however, the exact reason for such localization is unknown. Creatine kinase B (CKB), which replenishes local ATP pools, localizes near the ends of cultured primary mouse myotubes. To gain insight...

Mx1 and Mx2 key antiviral proteins are surprisingly lost in toothed whales

Benjamin A. Braun Amir Marcovitz J. Gray Camp Robin Jia Gill Bejerano

Published in Proceedings of the National Academy of Sciences

Viral outbreaks in dolphins and other Delphinoidea family members warrant investigation into the integrity of the cetacean immune system. The dynamin-like GTPase genes Myxovirus 1 (Mx1) and Mx2 defend mammals against a broad range of viral infections. Loss of Mx1 function in human and mice enhances infectivity by multiple RNA and DNA viruses, inclu...

Physical Characterization and In Vitro Biological Impact of Highly Aggregated Antibodies Separated into Size-Enriched Po...

Srivalli Telikepalli Heather E. Shinogle Prem S. Thapa Jae Hyun Kim Meghana Deshpande Vibha Jawa C. Russell Middaugh Linda Narhi Marisa K. Joubert David B. Volkin ...

Published in Journal of Pharmaceutical Sciences

An IgG2 monoclonal antibody (mAb) solution was subjected to stirring, generating high concentrations of nanometer and subvisible particles, which were then successfully size-enriched into different size bins by low-speed centrifugation or a combination of gravitational sedimentation and fluorescence-activated cell sorting (FACS). The size-fractiona...

Membrane Binding and Subcellular Localization of Retroviral Gag Proteins Are Differentially Regulated by MA Interactions... PDF available through Get Fulltext Research

Jingga Inlora David R. Collins Marc E. Trubin Ji Yeon J. Chung Akira Ono

Published in mBio

The matrix (MA) domain of HIV-1 mediates proper Gag localization and membrane binding via interaction with a plasma-membrane (PM)-specific acidic phospholipid, phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P2]. HIV-1 MA also interacts with RNA, which prevents Gag from binding to membranes containing phosphatidylserine, a prevalent cellular acidic...

Incidence and severity of myofiber branching with regeneration and aging PDF available through Get Fulltext Research

Christophe Pichavant Grace K Pavlath

Published in Skeletal Muscle

Background Myofibers with an abnormal branching cytoarchitecture are commonly found in muscular dystrophy and in regenerated or aged nondystrophic muscles. Such branched myofibers from dystrophic mice are more susceptible to damage than unbranched myofibers in vitro, suggesting that muscles containing a high percentage of these myofibers are more ...

Evidence in Support of RNA-Mediated Inhibition of Phosphatidylserine-Dependent HIV-1 Gag Membrane Binding in Cells PDF available through Get Fulltext Research

V. Chukkapalli Jingga Inlora G. C. Todd A. Ono

Published in Journal of Virology

The matrix domain promotes plasma-membrane-specific binding of HIV-1 Gag through interaction with an acidic lipid phosphatidylinositol-(4,5)-bisphosphate. In in vitro systems, matrix-bound RNA suppresses Gag interactions with phosphatidylserine, an acidic lipid prevalent in various cytoplasmic membranes, thereby enhancing the lipid specificity of t...

APR-246/PRIMA-1MET rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 m...

Jinfeng Shen E. H. van den Bogaard E. N. Kouwenhoven V. J. N. Bykov T. Rinne Q. Zhang G. S. Tjabringa C. Gilissen S. J. van Heeringen J. Schalkwijk ...

Published in Proceedings of the National Academy of Sciences

p53 and p63 share extensive sequence and structure homology. p53 is frequently mutated in cancer, whereas mutations in p63 cause developmental disorders manifested in ectodermal dysplasia, limb defects, and orofacial clefting. We have established primary adult skin keratinocytes from ectrodactyly, ectodermal dysplasia, and cleft lip/palate (EEC) sy...

APR-246/PRIMA-1(MET) rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63...

Shen, Jinfeng van den Bogaard, Ellen H Kouwenhoven, Evelyn N Bykov, Vladimir J N Rinne, Tuula Zhang, Qiang Tjabringa, Geuranne S Gilissen, Christian van Heeringen, Simon J Schalkwijk, Joost ...

Published in Proceedings of the National Academy of Sciences of the United States of America

p53 and p63 share extensive sequence and structure homology. p53 is frequently mutated in cancer, whereas mutations in p63 cause developmental disorders manifested in ectodermal dysplasia, limb defects, and orofacial clefting. We have established primary adult skin keratinocytes from ectrodactyly, ectodermal dysplasia, and cleft lip/palate (EEC) sy...

APR-246/PRIMA-1MET rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 m...

Jinfeng Shen van den Bogaard, E. H. Kouwenhoven, E. N. Bykov, V. J. N. Rinne, T. Zhang, Q. Tjabringa, G. S. Gilissen, C. van Heeringen, S. J. Schalkwijk, J. ...

Published in Proceedings of the National Academy of Sciences

p53 and p63 share extensive sequence and structure homology. p53 is frequently mutated in cancer, whereas mutations in p63 cause developmental disorders manifested in ectodermal dysplasia, limb defects, and orofacial clefting. We have established primary adult skin keratinocytes from ectrodactyly, ectodermal dysplasia, and cleft lip/palate (EEC) sy...

Involvement of lysosomal exocytosis in the excretion of mesoporous silica nanoparticles and enhancement of the drug deli...

Rolando Yanes Derrick Tarn Angela A Hwang Daniel P Ferris Sean P Sherman Courtney R Thomas Jie Lu April D Pyle Jeffrey I Zink Fuyuhiko Tamanoi ...

Published in Small Group Research

The exocytosis of phosphonate modified mesoporous silica nanoparticles (P-MSNs) is demonstrated and lysosomal exocytosis is identified as the mechanism responsible for this event. Regulation of P-MSN exocytosis can be achieved by inhibiting or accelerating lysosomal exocytosis. Slowing down P-MSN exocytosis enhances the drug delivery effect of CPT-...

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