Srivalli TelikepalliHeather E. ShinoglePrem S. ThapaJae Hyun KimMeghana DeshpandeVibha JawaC. Russell MiddaughLinda NarhiMarisa K. JoubertDavid B. Volkin
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An IgG2 monoclonal antibody (mAb) solution was subjected to stirring, generating high concentrations of nanometer and subvisible particles, which were then successfully size-enriched into different size bins by low-speed centrifugation or a combination of gravitational sedimentation and fluorescence-activated cell sorting (FACS). The size-fractiona...
A central question in muscle biology is how costameres are formed and become aligned with underlying myofibrils in mature tissues. Costameres are composed of focal adhesion proteins, including vinculin and paxillin, and anchor myofibril Z-bands to the sarcolemma. In the present study, we investigated the process of costamere formation (" costamerog...
The exocytosis of phosphonate modified mesoporous silica nanoparticles (P-MSNs) is demonstrated and lysosomal exocytosis is identified as the mechanism responsible for this event. Regulation of P-MSN exocytosis can be achieved by inhibiting or accelerating lysosomal exocytosis. Slowing down P-MSN exocytosis enhances the drug delivery effect of CPT-...
Christophe PichavantPierre ChapdelaineDaniel G CerriJean-Christophe DominiqueSimon P QuennevilleDaniel SkukJoe N KornegayJoão CS BizarioXiao XiaoJacques P Tremblay
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Adriana Simionescu-BankstonChristophe PichavantJames P. CannerLuciano H. ApponiYanru WangCraig SteedsJohn T. OlthoffJoseph J. BelantoJames M. ErvastiGrace K. Pavlath
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p53 and p63 share extensive sequence and structure homology. p53 is frequently mutated in cancer, whereas mutations in p63 cause developmental disorders manifested in ectodermal dysplasia, limb defects, and orofacial clefting. We have established primary adult skin keratinocytes from ectrodactyly, ectodermal dysplasia, and cleft lip/palate (EEC) sy...
Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) is present in oxidative modified LDL and accumulates in lesions of many chronic inflammatory diseases, such as atherosclerosis. In a microarray study, OxPAPC has been demonstrated to modulate the expression of >700 genes in human aortic endothelial cells. We found that the ...