PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2
Published in Oncogene
p53 mutations occur frequently in human tumors. The low-molecular-weight compound PRIMA-1 MET reactivates mutant p53, induces apoptosis in human tumor cells and inhibits tumor xenograft growth in vivo. Here, we show that PRIMA-1 MET induces mutant p53-dependent mito-chondria-mediated apoptosis through activation of caspase-2 with subsequent cytochr...